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This is a weekly feature that runs down the week鈥檚 top 10 announced funding rounds in the U.S. Check out last week鈥檚 biggest funding rounds here.

Just a couple of weeks until the end of the year and companies are still raising big rounds. The week was especially good for biotech, which led the way with two big raises. A space and defense startup also hit it big.

1. , $213M, biotech: A big biotech raise hit high on the list this week. Watertown, Massachusetts-based Tome Biosciences emerged from stealth with a $213 million combination Series A and B funding from investors that include the likes of Bio + Health and . The startup鈥檚 鈥渕olecular surgery鈥� technology, based on research licensed from the , is designed to allow the insertion of varying sizes of genetic material in the genome without damaging DNA. The company plans to use the tech to develop gene therapies for monogenic liver diseases and cell therapies for autoimmune diseases.

2. , $165M, biotech: If Bicara Therapeutics looks familiar, it’s because this isn鈥檛 its first time on this list. Boston-based Bicara Therapeutics raised a $108 million Series B co-led by and in March. This week, it is back with a $165 million Series C co-led by and 鈥� which is investing through its TPG Life Sciences Innovations, and . The company is developing biologics to fight tumors and is already in clinical trials for a head and neck cancer treatment. Founded in 2020, the company has raised $313 million, .

3. , $100M, space: Centennial, Colorado-based True Anomaly, which develops hardware and software systems to help space security and readiness, raised $100 million in a round led by this week. The company鈥檚 valuation was not disclosed, but it was not $1 billion. The startup helps the government and commercial customers keep an eye on threats to assets they have in space, such as satellites. The company鈥檚 Jackal autonomous orbital vehicles, which can detect objects in space, are slated to launch aboard 鈥榮 Transporter-10 mission next year. Founded in 2022, the company has raised .

4. , $66M, biotech: As one can tell, biotech really went big this week. Our third such startup already on the list, Emeryville, California-based Totus Medicines, closed a $66 million Series B financing led by . The firm specializes in small molecule drug discovery and development using covalent libraries and AI tools. Founded in 2020, the company has raised $106 million, .

5. , $57M, artificial intelligence: Essential AI鈥檚 round this week is a good example of what many AI startups did all this year 鈥� raise big money from corporates. The San Francisco-based startup announced it had $56.5 million in new funding led by , but other investors also were a who鈥檚 who of AI big tech 鈥� , , and others. The interest seems warranted, as the company is attempting to use AI to automate monotonous corporate tasks 鈥� which could be a big market. The company is calling its technology the 鈥淓nterprise Brain.鈥� Founded this year, the company already has raised more than $100 million, per .

6. , $52M, biotech: New York-based biotech firm Deep Apple Therapeutics raised a $52 million Series A from life sciences venture capital firm , which created and incubated the startup. Deep Apple is developing novel small molecule therapeutics through screening of AI-generated virtual libraries. This is the company鈥檚 first round of financing, .

7.(tied) , $50M, medical device: Pleasanton, California-based medical device startup Calyxo closed a $50 million Series D led by . Founded in 2016, the company has raised more than $97 million, .

7.(tied) , $50M, biotech: Seattle-based Parse Biosciences, a developer of scalable single-cell sequencing solutions, raised a $50 million Series C as a mix of equity and debt. No lead investor was announced for the equity portion. provided the debt facility. Founded in 2018, the company has raised $100 million, .

7.(tied) , $50M, biotech: Mountain View, California-based Twin Health locked up a $50 million round led by . The company uses a body digital twin to reverse or prevent chronic metabolic diseases. Founded in 2018, the company has raised nearly $250 million, .

10. , $48M, software: New York-based Stayntouch, a developer of cloud hotel property management software, secured a $48 million investment led by . Founded in 2012, the company has raised more than $60 million, .

Big global deals

The largest raise of the week was a really big one from across the Pacific.

• Singapore-based , an online shopping site, raised a $634 million corporate round from .

Methodology

We tracked the largest announced rounds in the Crunchbase database that were raised by U.S.-based companies for the seven-day period of Dec. 9 to Dec. 15. Although most announced rounds are represented in the database, there could be a small time lag as some rounds are reported late in the week.

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