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Want to keep track of the largest startup funding deals in 2026 with our curated list of $100 million-plus venture deals to U.S.-based companies? Check out The Crunchbase Megadeals Board.

This is a weekly feature that runs down the week’s top 10 announced funding rounds in the U.S. Check out last week’s biggest funding deal roundup here.

This week, most of the largest U.S. startup funding rounds centered around the sector one would suspect: artificial intelligence. This was true for the week’s largest venture financing, a $1.5 billion Series F for AI inference technology provider , as well as a majority of rounds in the Top 10. Beyond that, the next-biggest area for startup funding was biotech.

1. , $1.5B, AI inference technology: Baseten, a provider of systems software to run AI applications workloads, raised $1.5 billion in Series F funding, its fourth fundraise in 18 months. , , , and co-led the round, which set a $13 billion valuation for the San Francisco-based company.

2. , $1B, digital marketing: AppsFlyer, a San Francisco-based provider of data analytics with digital marketing as a core use case, reportedly secured more than $1 billion in a Series E funding round at a post-money valuation of $2.7 billion. Backers reportedly include , , and .

3. , $650M, AI inference technology: San Francisco-based Groq closed on $650 million in new funding led by and that it says will be used to scale its AI inference cloud technology and infrastructure. The investment comes just over six months after an acquihire-type transaction in which hired away its founder and key team members and licensed its technology.

4. , $330M, ophthalmic therapies: Ollin Biosciences, a developer of therapies for vision-threatening diseases, picked up $330 million in Series B funding. and led the financing for the Austin-based company.

5. , $320M, foundational AI: General Intuition, developer of a foundational AI model based on gameplay, secured $320 million in Series A funding at a $2.3 billion valuation. led the financing for the New York-based company, while backers including and participated.

6. , $250M, government software: Peregrine Technologies, provider of a platform used by public safety agencies and other government entities, secured $250 million in Series D financing. , , , , and led the financing, which set a $6.8 billion valuation for the San Francisco-based company.

7. (tied) , $200M, risk intelligence: Palo Alto, California-based Quantifind, developer of a risk intelligence platform for financial crime detection and national security operations, closed on $200 million in growth financing led by .

7. (tied) , $200M, foundational AI: San Francisco-based Mirendil, a frontier lab building systems that excel at AI R&D, says it raised a seed round of $200 million led by and . The startup also counts as a backer.

9. (tied) , $190M, AI infrastructure: AI networking infrastructure startup Upscale AI raised $190 million in Series A extension funding, bringing total financing to $500 million. led the round, which set a $2 billion valuation for the Santa Clara, California-based company.

9. (tied) , $190M, biotech: San Francisco-based Osanni Bio, a therapeutics platform focused on ophthalmic therapies and other treatments, secured $190 million in Series B funding led by .

Large non-US deals:

The week also brought some large European rounds:

, $569M, defense tech: Berlin-based defense tech startup Stark reportedly raised $569 million in a financing led by and .

, $546M, insurance: Paris-based health insurance startup Alan secured $460 million in new investment in primary and secondary equity led by .

Methodology

We tracked the largest announced rounds in the Crunchbase database that were raised by U.S.-based companies for the period of June 18-26. Although most announced rounds are represented in the database, there could be a small time lag as some rounds are reported late in the week.

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